Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells
Identifieur interne : 000124 ( an2020/Analysis ); précédent : 000123; suivant : 000125Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells
Auteurs : Anna-Lena Scherr ; Adam Jassowicz ; Anna Pat ; Christin Elssner ; Lars Ismail ; Nathalie Schmitt ; Paula Hoffmeister ; Lasse Neukirch ; Georg Gdynia ; Benjamin Goeppert ; Henning Schulze-Bergkamen ; Dirk J Ger ; Bruno Christian KöhlerSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2020.
Abstract
Autophagy is a catabolic process that enables cells to degrade obsolete content and refuel energy depots. In colorectal cancer (CRC) autophagy has been shown to promote tumorigenesis through energy delivery in the condition of uncontrolled proliferation. With this study, we aimed at evaluating whether autophagy sustains CRC cell viability and if it impacts therapy resistance. Initially, a colorectal cancer tissue micro array, containing mucosa (
Url:
DOI: 10.3390/ijms21031099
PubMed: 32046105
PubMed Central: 7038172
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000627
- to stream Pmc, to step Curation: 000627
- to stream Pmc, to step Checkpoint: 000117
- to stream Ncbi, to step Merge: 000F20
- to stream Ncbi, to step Curation: 000F20
- to stream Ncbi, to step Checkpoint: 000F20
- to stream Main, to step Merge: 000124
- to stream Main, to step Curation: 000124
- to stream Main, to step Exploration: 000124
- to stream an2020, to step Extraction: 000124
Links to Exploration step
PMC:7038172Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells</title><author><name sortKey="Scherr, Anna Lena" sort="Scherr, Anna Lena" uniqKey="Scherr A" first="Anna-Lena" last="Scherr">Anna-Lena Scherr</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Jassowicz, Adam" sort="Jassowicz, Adam" uniqKey="Jassowicz A" first="Adam" last="Jassowicz">Adam Jassowicz</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Pat, Anna" sort="Pat, Anna" uniqKey="Pat A" first="Anna" last="Pat">Anna Pat</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Elssner, Christin" sort="Elssner, Christin" uniqKey="Elssner C" first="Christin" last="Elssner">Christin Elssner</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Ismail, Lars" sort="Ismail, Lars" uniqKey="Ismail L" first="Lars" last="Ismail">Lars Ismail</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Schmitt, Nathalie" sort="Schmitt, Nathalie" uniqKey="Schmitt N" first="Nathalie" last="Schmitt">Nathalie Schmitt</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Hoffmeister, Paula" sort="Hoffmeister, Paula" uniqKey="Hoffmeister P" first="Paula" last="Hoffmeister">Paula Hoffmeister</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Neukirch, Lasse" sort="Neukirch, Lasse" uniqKey="Neukirch L" first="Lasse" last="Neukirch">Lasse Neukirch</name><affiliation><nlm:aff id="af2-ijms-21-01099">Clinical Cooperation Unit Applied Tumor Immunity, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg 69120, Germany;<email>lasse.neukirch@nct-heidelberg.de</email></nlm:aff></affiliation></author><author><name sortKey="Gdynia, Georg" sort="Gdynia, Georg" uniqKey="Gdynia G" first="Georg" last="Gdynia">Georg Gdynia</name><affiliation><nlm:aff id="af3-ijms-21-01099">Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>Georg.Gdynia@med.uni-heidelberg.de</email> (G.G.);<email>Benjamin.Goeppert@med.uni-heidelberg.de</email> (B.G.)</nlm:aff></affiliation></author><author><name sortKey="Goeppert, Benjamin" sort="Goeppert, Benjamin" uniqKey="Goeppert B" first="Benjamin" last="Goeppert">Benjamin Goeppert</name><affiliation><nlm:aff id="af3-ijms-21-01099">Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>Georg.Gdynia@med.uni-heidelberg.de</email> (G.G.);<email>Benjamin.Goeppert@med.uni-heidelberg.de</email> (B.G.)</nlm:aff></affiliation></author><author><name sortKey="Schulze Bergkamen, Henning" sort="Schulze Bergkamen, Henning" uniqKey="Schulze Bergkamen H" first="Henning" last="Schulze-Bergkamen">Henning Schulze-Bergkamen</name><affiliation><nlm:aff id="af4-ijms-21-01099">Department of Internal Medicine II, Marien Hospital, Wesel46483, Germany;<email>Henning.Schulze-Bergkamen@prohomine.de</email></nlm:aff></affiliation></author><author><name sortKey="J Ger, Dirk" sort="J Ger, Dirk" uniqKey="J Ger D" first="Dirk" last="J Ger">Dirk J Ger</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Kohler, Bruno Christian" sort="Kohler, Bruno Christian" uniqKey="Kohler B" first="Bruno Christian" last="Köhler">Bruno Christian Köhler</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32046105</idno><idno type="pmc">7038172</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038172</idno><idno type="RBID">PMC:7038172</idno><idno type="doi">10.3390/ijms21031099</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000627</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000627</idno><idno type="wicri:Area/Pmc/Curation">000627</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000627</idno><idno type="wicri:Area/Pmc/Checkpoint">000117</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000117</idno><idno type="wicri:Area/Ncbi/Merge">000F20</idno><idno type="wicri:Area/Ncbi/Curation">000F20</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F20</idno><idno type="wicri:Area/Main/Merge">000124</idno><idno type="wicri:Area/Main/Curation">000124</idno><idno type="wicri:Area/Main/Exploration">000124</idno><idno type="wicri:Area/an2020/Extraction">000124</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells</title><author><name sortKey="Scherr, Anna Lena" sort="Scherr, Anna Lena" uniqKey="Scherr A" first="Anna-Lena" last="Scherr">Anna-Lena Scherr</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Jassowicz, Adam" sort="Jassowicz, Adam" uniqKey="Jassowicz A" first="Adam" last="Jassowicz">Adam Jassowicz</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Pat, Anna" sort="Pat, Anna" uniqKey="Pat A" first="Anna" last="Pat">Anna Pat</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Elssner, Christin" sort="Elssner, Christin" uniqKey="Elssner C" first="Christin" last="Elssner">Christin Elssner</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Ismail, Lars" sort="Ismail, Lars" uniqKey="Ismail L" first="Lars" last="Ismail">Lars Ismail</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Schmitt, Nathalie" sort="Schmitt, Nathalie" uniqKey="Schmitt N" first="Nathalie" last="Schmitt">Nathalie Schmitt</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Hoffmeister, Paula" sort="Hoffmeister, Paula" uniqKey="Hoffmeister P" first="Paula" last="Hoffmeister">Paula Hoffmeister</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Neukirch, Lasse" sort="Neukirch, Lasse" uniqKey="Neukirch L" first="Lasse" last="Neukirch">Lasse Neukirch</name><affiliation><nlm:aff id="af2-ijms-21-01099">Clinical Cooperation Unit Applied Tumor Immunity, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg 69120, Germany;<email>lasse.neukirch@nct-heidelberg.de</email></nlm:aff></affiliation></author><author><name sortKey="Gdynia, Georg" sort="Gdynia, Georg" uniqKey="Gdynia G" first="Georg" last="Gdynia">Georg Gdynia</name><affiliation><nlm:aff id="af3-ijms-21-01099">Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>Georg.Gdynia@med.uni-heidelberg.de</email> (G.G.);<email>Benjamin.Goeppert@med.uni-heidelberg.de</email> (B.G.)</nlm:aff></affiliation></author><author><name sortKey="Goeppert, Benjamin" sort="Goeppert, Benjamin" uniqKey="Goeppert B" first="Benjamin" last="Goeppert">Benjamin Goeppert</name><affiliation><nlm:aff id="af3-ijms-21-01099">Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>Georg.Gdynia@med.uni-heidelberg.de</email> (G.G.);<email>Benjamin.Goeppert@med.uni-heidelberg.de</email> (B.G.)</nlm:aff></affiliation></author><author><name sortKey="Schulze Bergkamen, Henning" sort="Schulze Bergkamen, Henning" uniqKey="Schulze Bergkamen H" first="Henning" last="Schulze-Bergkamen">Henning Schulze-Bergkamen</name><affiliation><nlm:aff id="af4-ijms-21-01099">Department of Internal Medicine II, Marien Hospital, Wesel46483, Germany;<email>Henning.Schulze-Bergkamen@prohomine.de</email></nlm:aff></affiliation></author><author><name sortKey="J Ger, Dirk" sort="J Ger, Dirk" uniqKey="J Ger D" first="Dirk" last="J Ger">Dirk J Ger</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author><author><name sortKey="Kohler, Bruno Christian" sort="Kohler, Bruno Christian" uniqKey="Kohler B" first="Bruno Christian" last="Köhler">Bruno Christian Köhler</name><affiliation><nlm:aff id="af1-ijms-21-01099">National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg 69120, Germany;<email>anna-lena.scherr@nct-heidelberg.de</email> (A.-L.S.);<email>adam@jassowicz.com</email> (A.J.);<email>patoannaterezia@gmail.com</email> (A.P.);<email>Christin.Elssner@gmx.de</email> (C.E.);<email>lars.ismail1986@googlemail.com</email> (L.I.);<email>nathalie.schmitt@nct-heidelberg.de</email> (N.S.);<email>paula.hoffmeister@googlemail.com</email> (P.H.);<email>dirk.jaeger@nct-heidelberg.de</email> (D.J.)</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autophagy is a catabolic process that enables cells to degrade obsolete content and refuel energy depots. In colorectal cancer (CRC) autophagy has been shown to promote tumorigenesis through energy delivery in the condition of uncontrolled proliferation. With this study, we aimed at evaluating whether autophagy sustains CRC cell viability and if it impacts therapy resistance. Initially, a colorectal cancer tissue micro array, containing mucosa (<italic>n</italic> = 10), adenoma (<italic>n</italic> = 18) and adenocarcinoma (<italic>n</italic> = 49) spots, was stained for expression of essential autophagy proteins LC3b, Atg7, p62 and Beclin-1. Subsequently, central autophagy proteins were downregulated in CRC cells using siRNA technology. Viability assays, flow cytometry and immunoblotting were performed and three-dimensional cell culture was utilized to study autophagy in a tissue mimicking environment. In our study we found an upregulation of Atg7 in CRC. Furthermore, we identified Atg7 as crucial factor within the autophagy network for CRC cell viability. Its disruption induced cell death via triggering apoptosis and in combination with conventional chemotherapy it exerted synergistic effects in inducing CRC cell death. Cell death was strictly dependent on nuclear LC3b, since simultaneous knockdown of Atg7 and LC3b completely restored viability. This study unravels a novel cell death preventing function of Atg7 in interaction with LC3b, thereby unmasking a promising therapeutic target in CRC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. Ferlay</name></author><author><name sortKey="Shin, H R" uniqKey="Shin H">H.R. Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D. Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C. Mathers</name></author><author><name sortKey="Parkin, D M" uniqKey="Parkin D">D.M. Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I. Soerjomataram</name></author><author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R. Dikshit</name></author><author><name sortKey="Eser, S" uniqKey="Eser S">S. Eser</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C. Mathers</name></author><author><name sortKey="Rebelo, M" uniqKey="Rebelo M">M. Rebelo</name></author><author><name sortKey="Parkin, D M" uniqKey="Parkin D">D.M. Parkin</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D. Forman</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flanagan, J M" uniqKey="Flanagan J">J.M. Flanagan</name></author><author><name sortKey="Wilson, A" uniqKey="Wilson A">A. Wilson</name></author><author><name sortKey="Koo, C" uniqKey="Koo C">C. Koo</name></author><author><name sortKey="Masrour, N" uniqKey="Masrour N">N. Masrour</name></author><author><name sortKey="Gallon, J" uniqKey="Gallon J">J. Gallon</name></author><author><name sortKey="Loomis, E" uniqKey="Loomis E">E. Loomis</name></author><author><name sortKey="Flower, K" uniqKey="Flower K">K. Flower</name></author><author><name sortKey="Wilhelm Benartzi, C" uniqKey="Wilhelm Benartzi C">C. Wilhelm-Benartzi</name></author><author><name sortKey="Hergovich, A" uniqKey="Hergovich A">A. Hergovich</name></author><author><name sortKey="Cunnea, P" uniqKey="Cunnea P">P. Cunnea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N. Mizushima</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B. Levine</name></author><author><name sortKey="Cuervo, A M" uniqKey="Cuervo A">A.M. Cuervo</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D.J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, A M" uniqKey="Choi A">A.M. Choi</name></author><author><name sortKey="Ryter, S W" uniqKey="Ryter S">S.W. Ryter</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B. Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, Y F" uniqKey="Peng Y">Y.F. Peng</name></author><author><name sortKey="Shi, Y H" uniqKey="Shi Y">Y.H. Shi</name></author><author><name sortKey="Ding, Z B" uniqKey="Ding Z">Z.B. Ding</name></author><author><name sortKey="Ke, A W" uniqKey="Ke A">A.W. Ke</name></author><author><name sortKey="Gu, C Y" uniqKey="Gu C">C.Y. Gu</name></author><author><name sortKey="Hui, B" uniqKey="Hui B">B. Hui</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author><author><name sortKey="Qiu, S J" uniqKey="Qiu S">S.J. Qiu</name></author><author><name sortKey="Dai, Z" uniqKey="Dai Z">Z. Dai</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J. Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Espina, V" uniqKey="Espina V">V. Espina</name></author><author><name sortKey="Mariani, B D" uniqKey="Mariani B">B.D. Mariani</name></author><author><name sortKey="Gallagher, R I" uniqKey="Gallagher R">R.I. Gallagher</name></author><author><name sortKey="Tran, K" uniqKey="Tran K">K. Tran</name></author><author><name sortKey="Banks, S" uniqKey="Banks S">S. Banks</name></author><author><name sortKey="Wiedemann, J" uniqKey="Wiedemann J">J. Wiedemann</name></author><author><name sortKey="Huryk, H" uniqKey="Huryk H">H. Huryk</name></author><author><name sortKey="Mueller, C" uniqKey="Mueller C">C. Mueller</name></author><author><name sortKey="Adamo, L" uniqKey="Adamo L">L. Adamo</name></author><author><name sortKey="Deng, J" uniqKey="Deng J">J. Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, H Y" uniqKey="Zheng H">H.Y. Zheng</name></author><author><name sortKey="Zhang, X Y" uniqKey="Zhang X">X.Y. Zhang</name></author><author><name sortKey="Wang, X F" uniqKey="Wang X">X.F. Wang</name></author><author><name sortKey="Sun, B C" uniqKey="Sun B">B.C. Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wesselborg, S" uniqKey="Wesselborg S">S. Wesselborg</name></author><author><name sortKey="Stork, B" uniqKey="Stork B">B. Stork</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z. Xie</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D.J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaaf, M B" uniqKey="Schaaf M">M.B. Schaaf</name></author><author><name sortKey="Keulers, T G" uniqKey="Keulers T">T.G. Keulers</name></author><author><name sortKey="Vooijs, M A" uniqKey="Vooijs M">M.A. Vooijs</name></author><author><name sortKey="Rouschop, K M" uniqKey="Rouschop K">K.M. Rouschop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiong, J" uniqKey="Xiong J">J. Xiong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, J" uniqKey="Levy J">J. Levy</name></author><author><name sortKey="Cacheux, W" uniqKey="Cacheux W">W. Cacheux</name></author><author><name sortKey="Bara, M A" uniqKey="Bara M">M.A. Bara</name></author><author><name sortKey="L Ermitte, A" uniqKey="L Ermitte A">A. L’Hermitte</name></author><author><name sortKey="Lepage, P" uniqKey="Lepage P">P. Lepage</name></author><author><name sortKey="Fraudeau, M" uniqKey="Fraudeau M">M. Fraudeau</name></author><author><name sortKey="Trentesaux, C" uniqKey="Trentesaux C">C. Trentesaux</name></author><author><name sortKey="Lemarchand, J" uniqKey="Lemarchand J">J. Lemarchand</name></author><author><name sortKey="Durand, A" uniqKey="Durand A">A. Durand</name></author><author><name sortKey="Crain, A M" uniqKey="Crain A">A.M. Crain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gong, C" uniqKey="Gong C">C. Gong</name></author><author><name sortKey="Hu, C" uniqKey="Hu C">C. Hu</name></author><author><name sortKey="Gu, F" uniqKey="Gu F">F. Gu</name></author><author><name sortKey="Xia, Q" uniqKey="Xia Q">Q. Xia</name></author><author><name sortKey="Yao, C" uniqKey="Yao C">C. Yao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Qiang, L" uniqKey="Qiang L">L. Qiang</name></author><author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apetoh, L" uniqKey="Apetoh L">L. Apetoh</name></author><author><name sortKey="Ghiringhelli, F" uniqKey="Ghiringhelli F">F. Ghiringhelli</name></author><author><name sortKey="Tesniere, A" uniqKey="Tesniere A">A. Tesniere</name></author><author><name sortKey="Obeid, M" uniqKey="Obeid M">M. Obeid</name></author><author><name sortKey="Ortiz, C" uniqKey="Ortiz C">C. Ortiz</name></author><author><name sortKey="Criollo, A" uniqKey="Criollo A">A. Criollo</name></author><author><name sortKey="Mignot, G" uniqKey="Mignot G">G. Mignot</name></author><author><name sortKey="Maiuri, M C" uniqKey="Maiuri M">M.C. Maiuri</name></author><author><name sortKey="Ullrich, E" uniqKey="Ullrich E">E. Ullrich</name></author><author><name sortKey="Saulnier, P" uniqKey="Saulnier P">P. Saulnier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tesniere, A" uniqKey="Tesniere A">A. Tesniere</name></author><author><name sortKey="Schlemmer, F" uniqKey="Schlemmer F">F. Schlemmer</name></author><author><name sortKey="Boige, V" uniqKey="Boige V">V. Boige</name></author><author><name sortKey="Kepp, O" uniqKey="Kepp O">O. Kepp</name></author><author><name sortKey="Martins, I" uniqKey="Martins I">I. Martins</name></author><author><name sortKey="Ghiringhelli, F" uniqKey="Ghiringhelli F">F. Ghiringhelli</name></author><author><name sortKey="Aymeric, L" uniqKey="Aymeric L">L. Aymeric</name></author><author><name sortKey="Michaud, M" uniqKey="Michaud M">M. Michaud</name></author><author><name sortKey="Apetoh, L" uniqKey="Apetoh L">L. Apetoh</name></author><author><name sortKey="Barault, L" uniqKey="Barault L">L. Barault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barker, H E" uniqKey="Barker H">H.E. Barker</name></author><author><name sortKey="Paget, J T" uniqKey="Paget J">J.T. Paget</name></author><author><name sortKey="Khan, A A" uniqKey="Khan A">A.A. Khan</name></author><author><name sortKey="Harrington, K J" uniqKey="Harrington K">K.J. Harrington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S. Yang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Contino, G" uniqKey="Contino G">G. Contino</name></author><author><name sortKey="Liesa, M" uniqKey="Liesa M">M. Liesa</name></author><author><name sortKey="Sahin, E" uniqKey="Sahin E">E. Sahin</name></author><author><name sortKey="Ying, H" uniqKey="Ying H">H. Ying</name></author><author><name sortKey="Bause, A" uniqKey="Bause A">A. Bause</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Stommel, J M" uniqKey="Stommel J">J.M. Stommel</name></author><author><name sortKey="Dell Ntonio, G" uniqKey="Dell Ntonio G">G. Dell’antonio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, J Y" uniqKey="Guo J">J.Y. Guo</name></author><author><name sortKey="Karsli Uzunbas, G" uniqKey="Karsli Uzunbas G">G. Karsli-Uzunbas</name></author><author><name sortKey="Mathew, R" uniqKey="Mathew R">R. Mathew</name></author><author><name sortKey="Aisner, S C" uniqKey="Aisner S">S.C. Aisner</name></author><author><name sortKey="Kamphorst, J J" uniqKey="Kamphorst J">J.J. Kamphorst</name></author><author><name sortKey="Strohecker, A M" uniqKey="Strohecker A">A.M. Strohecker</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Price, S" uniqKey="Price S">S. Price</name></author><author><name sortKey="Lu, W" uniqKey="Lu W">W. Lu</name></author><author><name sortKey="Teng, X" uniqKey="Teng X">X. Teng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, K" uniqKey="Sato K">K. Sato</name></author><author><name sortKey="Tsuchihara, K" uniqKey="Tsuchihara K">K. Tsuchihara</name></author><author><name sortKey="Fujii, S" uniqKey="Fujii S">S. Fujii</name></author><author><name sortKey="Sugiyama, M" uniqKey="Sugiyama M">M. Sugiyama</name></author><author><name sortKey="Goya, T" uniqKey="Goya T">T. Goya</name></author><author><name sortKey="Atomi, Y" uniqKey="Atomi Y">Y. Atomi</name></author><author><name sortKey="Ueno, T" uniqKey="Ueno T">T. Ueno</name></author><author><name sortKey="Ochiai, A" uniqKey="Ochiai A">A. Ochiai</name></author><author><name sortKey="Esumi, H" uniqKey="Esumi H">H. Esumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selvakumaran, M" uniqKey="Selvakumaran M">M. Selvakumaran</name></author><author><name sortKey="Amaravadi, R K" uniqKey="Amaravadi R">R.K. Amaravadi</name></author><author><name sortKey="Vasilevskaya, I A" uniqKey="Vasilevskaya I">I.A. Vasilevskaya</name></author><author><name sortKey="O Wyer, P J" uniqKey="O Wyer P">P.J. O’Dwyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanislav, J" uniqKey="Stanislav J">J. Stanislav</name></author><author><name sortKey="Mls, J" uniqKey="Mls J">J. Mls</name></author><author><name sortKey="Cervinka, M" uniqKey="Cervinka M">M. Cervinka</name></author><author><name sortKey="Rudolf, E" uniqKey="Rudolf E">E. Rudolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garrett, W S" uniqKey="Garrett W">W.S. Garrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strohecker, A M" uniqKey="Strohecker A">A.M. Strohecker</name></author><author><name sortKey="Guo, J Y" uniqKey="Guo J">J.Y. Guo</name></author><author><name sortKey="Karsli Uzunbas, G" uniqKey="Karsli Uzunbas G">G. Karsli-Uzunbas</name></author><author><name sortKey="Price, S M" uniqKey="Price S">S.M. Price</name></author><author><name sortKey="Chen, G J" uniqKey="Chen G">G.J. Chen</name></author><author><name sortKey="Mathew, R" uniqKey="Mathew R">R. Mathew</name></author><author><name sortKey="Mcmahon, M" uniqKey="Mcmahon M">M. McMahon</name></author><author><name sortKey="White, E" uniqKey="White E">E. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, J" uniqKey="Levy J">J. Levy</name></author><author><name sortKey="Romagnolo, B" uniqKey="Romagnolo B">B. Romagnolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, L" uniqKey="He L">L. He</name></author><author><name sortKey="Wei, J Y" uniqKey="Wei J">J.Y. Wei</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author><author><name sortKey="Zhao, W D" uniqKey="Zhao W">W.D. Zhao</name></author><author><name sortKey="Chen, Y H" uniqKey="Chen Y">Y.H. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lenander, C" uniqKey="Lenander C">C. Lenander</name></author><author><name sortKey="Roblick, U J" uniqKey="Roblick U">U.J. Roblick</name></author><author><name sortKey="Habermann, J K" uniqKey="Habermann J">J.K. Habermann</name></author><author><name sortKey="Ost, A" uniqKey="Ost A">A. Ost</name></author><author><name sortKey="Tryggvason, K" uniqKey="Tryggvason K">K. Tryggvason</name></author><author><name sortKey="Auer, G" uniqKey="Auer G">G. Auer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marangon Junior, H" uniqKey="Marangon Junior H">H. Marangon Junior</name></author><author><name sortKey="Rocha, V N" uniqKey="Rocha V">V.N. Rocha</name></author><author><name sortKey="Leite, C F" uniqKey="Leite C">C.F. Leite</name></author><author><name sortKey="De Aguiar, M C" uniqKey="De Aguiar M">M.C. de Aguiar</name></author><author><name sortKey="Souza, P E" uniqKey="Souza P">P.E. Souza</name></author><author><name sortKey="Horta, M C" uniqKey="Horta M">M.C. Horta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez Puerto, M C" uniqKey="Gomez Puerto M">M.C. Gomez-Puerto</name></author><author><name sortKey="Folkerts, H" uniqKey="Folkerts H">H. Folkerts</name></author><author><name sortKey="Wierenga, A T" uniqKey="Wierenga A">A.T. Wierenga</name></author><author><name sortKey="Schepers, K" uniqKey="Schepers K">K. Schepers</name></author><author><name sortKey="Schuringa, J J" uniqKey="Schuringa J">J.J. Schuringa</name></author><author><name sortKey="Coffer, P J" uniqKey="Coffer P">P.J. Coffer</name></author><author><name sortKey="Vellenga, E" uniqKey="Vellenga E">E. Vellenga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komatsu, M" uniqKey="Komatsu M">M. Komatsu</name></author><author><name sortKey="Waguri, S" uniqKey="Waguri S">S. Waguri</name></author><author><name sortKey="Ueno, T" uniqKey="Ueno T">T. Ueno</name></author><author><name sortKey="Iwata, J" uniqKey="Iwata J">J. Iwata</name></author><author><name sortKey="Murata, S" uniqKey="Murata S">S. Murata</name></author><author><name sortKey="Tanida, I" uniqKey="Tanida I">I. Tanida</name></author><author><name sortKey="Ezaki, J" uniqKey="Ezaki J">J. Ezaki</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N. Mizushima</name></author><author><name sortKey="Ohsumi, Y" uniqKey="Ohsumi Y">Y. Ohsumi</name></author><author><name sortKey="Uchiyama, Y" uniqKey="Uchiyama Y">Y. Uchiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, C" uniqKey="Xie C">C. Xie</name></author><author><name sortKey="Ginet, V" uniqKey="Ginet V">V. Ginet</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name></author><author><name sortKey="Koike, M" uniqKey="Koike M">M. Koike</name></author><author><name sortKey="Zhou, K" uniqKey="Zhou K">K. Zhou</name></author><author><name sortKey="Li, T" uniqKey="Li T">T. Li</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Uchiyama, Y" uniqKey="Uchiyama Y">Y. Uchiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donde, A" uniqKey="Donde A">A. Donde</name></author><author><name sortKey="Sun, M" uniqKey="Sun M">M. Sun</name></author><author><name sortKey="Jeong, Y H" uniqKey="Jeong Y">Y.H. Jeong</name></author><author><name sortKey="Wen, X" uniqKey="Wen X">X. Wen</name></author><author><name sortKey="Ling, J" uniqKey="Ling J">J. Ling</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name></author><author><name sortKey="Braunstein, K" uniqKey="Braunstein K">K. Braunstein</name></author><author><name sortKey="Nie, S" uniqKey="Nie S">S. Nie</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, W" uniqKey="Kang W">W. Kang</name></author><author><name sortKey="Ishida, E" uniqKey="Ishida E">E. Ishida</name></author><author><name sortKey="Yamatoya, K" uniqKey="Yamatoya K">K. Yamatoya</name></author><author><name sortKey="Nakamura, A" uniqKey="Nakamura A">A. Nakamura</name></author><author><name sortKey="Miyado, M" uniqKey="Miyado M">M. Miyado</name></author><author><name sortKey="Miyamoto, Y" uniqKey="Miyamoto Y">Y. Miyamoto</name></author><author><name sortKey="Iwai, M" uniqKey="Iwai M">M. Iwai</name></author><author><name sortKey="Tatsumi, K" uniqKey="Tatsumi K">K. Tatsumi</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T. Saito</name></author><author><name sortKey="Saito, K" uniqKey="Saito K">K. Saito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, R" uniqKey="Huang R">R. Huang</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author><author><name sortKey="Wan, W" uniqKey="Wan W">W. Wan</name></author><author><name sortKey="Shou, X" uniqKey="Shou X">X. Shou</name></author><author><name sortKey="Qian, J" uniqKey="Qian J">J. Qian</name></author><author><name sortKey="You, Z" uniqKey="You Z">Z. You</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name></author><author><name sortKey="Chang, C" uniqKey="Chang C">C. Chang</name></author><author><name sortKey="Zhou, T" uniqKey="Zhou T">T. Zhou</name></author><author><name sortKey="Lippincott Schwartz, J" uniqKey="Lippincott Schwartz J">J. Lippincott-Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kraft, L J" uniqKey="Kraft L">L.J. Kraft</name></author><author><name sortKey="Manral, P" uniqKey="Manral P">P. Manral</name></author><author><name sortKey="Dowler, J" uniqKey="Dowler J">J. Dowler</name></author><author><name sortKey="Kenworthy, A K" uniqKey="Kenworthy A">A.K. Kenworthy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dou, Z" uniqKey="Dou Z">Z. Dou</name></author><author><name sortKey="Ivanov, A" uniqKey="Ivanov A">A. Ivanov</name></author><author><name sortKey="Adams, P D" uniqKey="Adams P">P.D. Adams</name></author><author><name sortKey="Berger, S L" uniqKey="Berger S">S.L. Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dou, Z" uniqKey="Dou Z">Z. Dou</name></author><author><name sortKey="Xu, C" uniqKey="Xu C">C. Xu</name></author><author><name sortKey="Donahue, G" uniqKey="Donahue G">G. Donahue</name></author><author><name sortKey="Shimi, T" uniqKey="Shimi T">T. Shimi</name></author><author><name sortKey="Pan, J A" uniqKey="Pan J">J.A. Pan</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name></author><author><name sortKey="Ivanov, A" uniqKey="Ivanov A">A. Ivanov</name></author><author><name sortKey="Capell, B C" uniqKey="Capell B">B.C. Capell</name></author><author><name sortKey="Drake, A M" uniqKey="Drake A">A.M. Drake</name></author><author><name sortKey="Shah, P P" uniqKey="Shah P">P.P. Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baron, O" uniqKey="Baron O">O. Baron</name></author><author><name sortKey="Boudi, A" uniqKey="Boudi A">A. Boudi</name></author><author><name sortKey="Dias, C" uniqKey="Dias C">C. Dias</name></author><author><name sortKey="Schilling, M" uniqKey="Schilling M">M. Schilling</name></author><author><name sortKey="Nolle, A" uniqKey="Nolle A">A. Nolle</name></author><author><name sortKey="Vizcay Barrena, G" uniqKey="Vizcay Barrena G">G. Vizcay-Barrena</name></author><author><name sortKey="Rattray, I" uniqKey="Rattray I">I. Rattray</name></author><author><name sortKey="Jungbluth, H" uniqKey="Jungbluth H">H. Jungbluth</name></author><author><name sortKey="Scheper, W" uniqKey="Scheper W">W. Scheper</name></author><author><name sortKey="Fleck, R A" uniqKey="Fleck R">R.A. Fleck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fu, N" uniqKey="Fu N">N. Fu</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michaud, M" uniqKey="Michaud M">M. Michaud</name></author><author><name sortKey="Martins, I" uniqKey="Martins I">I. Martins</name></author><author><name sortKey="Sukkurwala, A Q" uniqKey="Sukkurwala A">A.Q. Sukkurwala</name></author><author><name sortKey="Adjemian, S" uniqKey="Adjemian S">S. Adjemian</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y. Ma</name></author><author><name sortKey="Pellegatti, P" uniqKey="Pellegatti P">P. Pellegatti</name></author><author><name sortKey="Shen, S" uniqKey="Shen S">S. Shen</name></author><author><name sortKey="Kepp, O" uniqKey="Kepp O">O. Kepp</name></author><author><name sortKey="Scoazec, M" uniqKey="Scoazec M">M. Scoazec</name></author><author><name sortKey="Mignot, G" uniqKey="Mignot G">G. Mignot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michaud, M" uniqKey="Michaud M">M. Michaud</name></author><author><name sortKey="Xie, X" uniqKey="Xie X">X. Xie</name></author><author><name sortKey="Bravo San Pedro, J M" uniqKey="Bravo San Pedro J">J.M. Bravo-San Pedro</name></author><author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name></author><author><name sortKey="White, E" uniqKey="White E">E. White</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, I H" uniqKey="Lee I">I.H. Lee</name></author><author><name sortKey="Kawai, Y" uniqKey="Kawai Y">Y. Kawai</name></author><author><name sortKey="Fergusson, M M" uniqKey="Fergusson M">M.M. Fergusson</name></author><author><name sortKey="Rovira, I I" uniqKey="Rovira I">I.I. Rovira</name></author><author><name sortKey="Bishop, A J" uniqKey="Bishop A">A.J. Bishop</name></author><author><name sortKey="Motoyama, N" uniqKey="Motoyama N">N. Motoyama</name></author><author><name sortKey="Cao, L" uniqKey="Cao L">L. Cao</name></author><author><name sortKey="Finkel, T" uniqKey="Finkel T">T. Finkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, E Y" uniqKey="Liu E">E.Y. Liu</name></author><author><name sortKey="Xu, N" uniqKey="Xu N">N. Xu</name></author><author><name sortKey="O Rey, J" uniqKey="O Rey J">J. O’Prey</name></author><author><name sortKey="Lao, L Y" uniqKey="Lao L">L.Y. Lao</name></author><author><name sortKey="Joshi, S" uniqKey="Joshi S">S. Joshi</name></author><author><name sortKey="Long, J S" uniqKey="Long J">J.S. Long</name></author><author><name sortKey="O Rey, M" uniqKey="O Rey M">M. O’Prey</name></author><author><name sortKey="Croft, D R" uniqKey="Croft D">D.R. Croft</name></author><author><name sortKey="Beaumatin, F" uniqKey="Beaumatin F">F. Beaumatin</name></author><author><name sortKey="Baudot, A D" uniqKey="Baudot A">A.D. Baudot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burma, S" uniqKey="Burma S">S. Burma</name></author><author><name sortKey="Chen, B P" uniqKey="Chen B">B.P. Chen</name></author><author><name sortKey="Murphy, M" uniqKey="Murphy M">M. Murphy</name></author><author><name sortKey="Kurimasa, A" uniqKey="Kurimasa A">A. Kurimasa</name></author><author><name sortKey="Chen, D J" uniqKey="Chen D">D.J. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koehler, B C" uniqKey="Koehler B">B.C. Koehler</name></author><author><name sortKey="Scherr, A L" uniqKey="Scherr A">A.L. Scherr</name></author><author><name sortKey="Lorenz, S" uniqKey="Lorenz S">S. Lorenz</name></author><author><name sortKey="Elssner, C" uniqKey="Elssner C">C. Elssner</name></author><author><name sortKey="Kautz, N" uniqKey="Kautz N">N. Kautz</name></author><author><name sortKey="Welte, S" uniqKey="Welte S">S. Welte</name></author><author><name sortKey="Jaeger, D" uniqKey="Jaeger D">D. Jaeger</name></author><author><name sortKey="Urbanik, T" uniqKey="Urbanik T">T. Urbanik</name></author><author><name sortKey="Schulze Bergkamen, H" uniqKey="Schulze Bergkamen H">H. Schulze-Bergkamen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koehler, B C" uniqKey="Koehler B">B.C. Koehler</name></author><author><name sortKey="Scherr, A L" uniqKey="Scherr A">A.L. Scherr</name></author><author><name sortKey="Lorenz, S" uniqKey="Lorenz S">S. Lorenz</name></author><author><name sortKey="Urbanik, T" uniqKey="Urbanik T">T. Urbanik</name></author><author><name sortKey="Kautz, N" uniqKey="Kautz N">N. Kautz</name></author><author><name sortKey="Elssner, C" uniqKey="Elssner C">C. Elssner</name></author><author><name sortKey="Welte, S" uniqKey="Welte S">S. Welte</name></author><author><name sortKey="Bermejo, J L" uniqKey="Bermejo J">J.L. Bermejo</name></author><author><name sortKey="Jager, D" uniqKey="Jager D">D. Jager</name></author><author><name sortKey="Schulze Bergkamen, H" uniqKey="Schulze Bergkamen H">H. Schulze-Bergkamen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, I H" uniqKey="Lee I">I.H. Lee</name></author><author><name sortKey="Cao, L" uniqKey="Cao L">L. Cao</name></author><author><name sortKey="Mostoslavsky, R" uniqKey="Mostoslavsky R">R. Mostoslavsky</name></author><author><name sortKey="Lombard, D B" uniqKey="Lombard D">D.B. Lombard</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Bruns, N E" uniqKey="Bruns N">N.E. Bruns</name></author><author><name sortKey="Tsokos, M" uniqKey="Tsokos M">M. Tsokos</name></author><author><name sortKey="Alt, F W" uniqKey="Alt F">F.W. Alt</name></author><author><name sortKey="Finkel, T" uniqKey="Finkel T">T. Finkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scherr, A L" uniqKey="Scherr A">A.L. Scherr</name></author><author><name sortKey="Gdynia, G" uniqKey="Gdynia G">G. Gdynia</name></author><author><name sortKey="Salou, M" uniqKey="Salou M">M. Salou</name></author><author><name sortKey="Radhakrishnan, P" uniqKey="Radhakrishnan P">P. Radhakrishnan</name></author><author><name sortKey="Duglova, K" uniqKey="Duglova K">K. Duglova</name></author><author><name sortKey="Heller, A" uniqKey="Heller A">A. Heller</name></author><author><name sortKey="Keim, S" uniqKey="Keim S">S. Keim</name></author><author><name sortKey="Kautz, N" uniqKey="Kautz N">N. Kautz</name></author><author><name sortKey="Jassowicz, A" uniqKey="Jassowicz A">A. Jassowicz</name></author><author><name sortKey="Elssner, C" uniqKey="Elssner C">C. Elssner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koehler, B C" uniqKey="Koehler B">B.C. Koehler</name></author><author><name sortKey="Jassowicz, A" uniqKey="Jassowicz A">A. Jassowicz</name></author><author><name sortKey="Scherr, A L" uniqKey="Scherr A">A.L. Scherr</name></author><author><name sortKey="Lorenz, S" uniqKey="Lorenz S">S. Lorenz</name></author><author><name sortKey="Radhakrishnan, P" uniqKey="Radhakrishnan P">P. Radhakrishnan</name></author><author><name sortKey="Kautz, N" uniqKey="Kautz N">N. Kautz</name></author><author><name sortKey="Elssner, C" uniqKey="Elssner C">C. Elssner</name></author><author><name sortKey="Weiss, J" uniqKey="Weiss J">J. Weiss</name></author><author><name sortKey="Jaeger, D" uniqKey="Jaeger D">D. Jaeger</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M. Schneider</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Elssner, Christin" sort="Elssner, Christin" uniqKey="Elssner C" first="Christin" last="Elssner">Christin Elssner</name><name sortKey="Gdynia, Georg" sort="Gdynia, Georg" uniqKey="Gdynia G" first="Georg" last="Gdynia">Georg Gdynia</name><name sortKey="Goeppert, Benjamin" sort="Goeppert, Benjamin" uniqKey="Goeppert B" first="Benjamin" last="Goeppert">Benjamin Goeppert</name><name sortKey="Hoffmeister, Paula" sort="Hoffmeister, Paula" uniqKey="Hoffmeister P" first="Paula" last="Hoffmeister">Paula Hoffmeister</name><name sortKey="Ismail, Lars" sort="Ismail, Lars" uniqKey="Ismail L" first="Lars" last="Ismail">Lars Ismail</name><name sortKey="J Ger, Dirk" sort="J Ger, Dirk" uniqKey="J Ger D" first="Dirk" last="J Ger">Dirk J Ger</name><name sortKey="Jassowicz, Adam" sort="Jassowicz, Adam" uniqKey="Jassowicz A" first="Adam" last="Jassowicz">Adam Jassowicz</name><name sortKey="Kohler, Bruno Christian" sort="Kohler, Bruno Christian" uniqKey="Kohler B" first="Bruno Christian" last="Köhler">Bruno Christian Köhler</name><name sortKey="Neukirch, Lasse" sort="Neukirch, Lasse" uniqKey="Neukirch L" first="Lasse" last="Neukirch">Lasse Neukirch</name><name sortKey="Pat, Anna" sort="Pat, Anna" uniqKey="Pat A" first="Anna" last="Pat">Anna Pat</name><name sortKey="Scherr, Anna Lena" sort="Scherr, Anna Lena" uniqKey="Scherr A" first="Anna-Lena" last="Scherr">Anna-Lena Scherr</name><name sortKey="Schmitt, Nathalie" sort="Schmitt, Nathalie" uniqKey="Schmitt N" first="Nathalie" last="Schmitt">Nathalie Schmitt</name><name sortKey="Schulze Bergkamen, Henning" sort="Schulze Bergkamen, Henning" uniqKey="Schulze Bergkamen H" first="Henning" last="Schulze-Bergkamen">Henning Schulze-Bergkamen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/an2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000124 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd -nk 000124 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= an2020
|étape= Analysis
|type= RBID
|clé= PMC:7038172
|texte= Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i -Sk "pubmed:32046105" \
| HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |